Microbiota restoration for recurrent Clostridioides difficile : Getting one step closer every day!

intestinal microbiota transplantation for recurrent clostridium difficile infection

One step closer to personalized genomic medicine.

We are rapidly entering an era of personalized genomic medicine. The complete sequencing of the human genome was first announced .9 years ago, and soon afterwards the annotated human genome sequence was available online. Today, DNA analysis that was once considered onerous has become routine. Although not perfect, ‘next-generation’ techniques for rapid and low-cost sequencing have been applied ...

One step closer to understanding poststroke fatigue.

Neurology 2012;79:1414–1415 Pathologic fatigue is common in neurologic disorders and can be defined as “a state of weariness unrelated to previous exertion levels which is usually not ameliorated by rest.”1 A case definition for poststroke fatigue (PSF) has been developed,2 based on this definition,1 to identify clinically important fatigue in stroke survivors.2 The frequency of PSF ranges from...

Aspergillus PCR: one step closer to standardization.

PCR has been used as an aid in the diagnosis of invasive aspergillosis for almost 2 decades. A lack of standardization has limited both its acceptance as a diagnostic tool and multicenter clinical evaluations, preventing its inclusion in disease-defining criteria. In 2006, the European Aspergillus PCR Initiative was formed. The aim of the initiative was to provide optimal standardized protocols...

Topological Data Analysis of Clostridioides difficile Infection and Fecal Microbiota Transplantation

Computational topologists recently developed a method, called persistent homology to analyze data presented in terms of similarity or dissimilarity. Indeed, persistent homology studies the evolution of topological features in terms of a single index, and is able to capture higher order features beyond the usual clustering techniques. There are three descriptive statistics of persistent homology...